Using her young daughter Mathilde as leverage, Safin blackmailed her into smuggling Heracles into Belmarsh prison by infecting herself. Safin meets Madeleine Swann in her officeįor the first time in many years, Safin approached Madeleine Swann, now a psychiatrist attending to the imprisoned leader of SPECTRE – Ernst Stavro Blofeld. With SPECTRE fatally crippled and the weapon firmly in his hands thanks to CIA turncoat, Logan Ash, Safin assimilated their assets and manpower notably reacquiring the The Poison Garden and turning his attention to mass production of Heracles.

However, the DNA-targeting weapon instead singled out the observing board members and massacred them. Shortly afterwards, at a Cuban meeting of SPECTRE, they unleashed Heracles in an attempted assassination on former British agent James Bond. However, SPECTRE also wanted the technology and the opportunistic Safin took full advantage of their raid on its London laboratory instructing Obruchev to not resist his captors, and secretly reprogram the stolen weapon to exact revenge on his family's killers. Years later, Safin sought to acquire a highly-classified British nanoweapon named ' Heracles' and successfully bought the services of its lead scientist Dr. Instead of killing her, Safin saved and spared her life before leaving. However, after temporarily lying motionless, he recuperated and pursued her across a frozen lake into which she fell and began to drown. Finding only his daughter Madeleine and her mother, he killed the latter and was shot and injured by the young girl. In the late 1990s, Safin, wearing a traditional Japanese Noh mask to cover his scarred face, attempted to murder Mr. ' A man once came to our house to kill my father, he didn't know I was upstairs, playing in my bedroom, or that papa kept a Beretta Nine-millimeter under the sink with the bleach.' ― Madeleine Swann to James Bond

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